Description

1,3:4,6-Bis-o-(4-Methoxybenzylidene)- D-Mannitol is a specialized chiral derivative of D-mannitol, widely recognized as a key intermediate in asymmetric synthesis and pharmaceutical research. Its value lies in its role as a versatile building block for constructing complex molecular architectures, particularly in the development of chiral ligands, catalysts, and active pharmaceutical ingredients (APIs). This high-purity compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality chiral intermediates to advance their synthetic programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel chiral drugs and active pharmaceutical ingredients (APIs).
• Chiral Ligand & Catalyst Synthesis: Used as a starting material for developing enantioselective catalysts and ligands for asymmetric transformations.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex, high-value specialty chemicals and flavors/fragrances.
• Academic & Industrial R&D: A valuable tool for research in organic chemistry, medicinal chemistry, and process development.
• Agrochemical Intermediate: Potential use in the synthesis of chiral active ingredients for crop protection products.
• Material Science: Investigated for the development of chiral polymers and advanced functional materials.

Basic Information

Product Name	1,3:4,6-Bis-o-(4-Methoxybenzylidene)- D-Mannitol
CAS No.	114935-17-0
Molecular Formula	C22H24O8
Molecular Weight	416.42 g/mol
Synonyms	1,3:4,6-Di-O-(4-Methoxybenzylidene)-D-mannitol; Di-p-methoxybenzylidene-D-mannitol; 1,3:4,6-Bis-O-(4-methoxybenzylidene)-D-mannitol; D-Mannitol 1,3:4,6-bis-O-(p-methoxybenzylidene) acetal; (3aR,4S,7R,7aS)-2,2-Dimethyl-4,7-bis(4-methoxyphenyl)tetrahydro-4H,7H-[1,3]dioxolo[4,5-d][1,3]dioxine; 1,3:4,6-Di-O-(p-methoxybenzylidene)-D-mannitol
EINECS	Contact for details

Quality Control

Our 1,3:4,6-Bis-o-(4-Methoxybenzylidene)- D-Mannitol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and synthesis. We provide full traceability and Certificates of Analysis (COA) are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Melting Point	Specified range available on COA
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.