Description

Boc-L-2-Fluorophe CAS NO 114873-00-6 is a high-purity, fluorinated, N-Boc-protected amino acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex peptide and peptidomimetic structures, particularly where the introduction of fluorine atoms is desired to modulate biological activity, metabolic stability, and physicochemical properties. This compound is essential for researchers and manufacturers in pharmaceutical R&D, peptide synthesis, and the development of novel bioactive molecules.

Application

• Pharmaceutical Intermediates: Key chiral synthon for the synthesis of fluorinated peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate fluorinated phenylalanine residues.
• Proteomics & Biochemical Research: A valuable tool for creating fluorinated analogs of native peptides to study protein structure, function, and interactions.
• Agrochemical Development: Building block for synthesizing novel fluorinated compounds with potential pesticidal or herbicidal activity.
• Material Science: Precursor for specialty polymers and advanced materials where fluorine content imparts specific characteristics like hydrophobicity or chemical resistance.
• Diagnostic Agent Synthesis: Used in the development of fluorinated tracers and contrast agents for imaging technologies.

Basic Information

Product Name	Boc-L-2-Fluorophe CAS NO 114873-00-6
CAS No.	114873-00-6
Molecular Formula	C₁₄H₁₈FNO₄
Molecular Weight	283.30 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-2-fluoro-L-phenylalanine; Boc-2-F-L-Phe-OH; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(2-fluorophenyl)propanoic acid; tert-Butyl (2S)-2-amino-3-(2-fluorophenyl)propanoate; N-Boc-2-fluoro-L-phenylalanine; Boc-L-2-Fluorophenylalanine; 2-Fluoro-L-phenylalanine N-Boc derivative; Fmoc-L-2-Fluorophe precursor
EINECS	Contact for details

Quality Control

Our Boc-L-2-Fluorophe is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% ee
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.