Description

D-Proline, 4-Hydroxy-, Methyl Ester, Hydrochloride (1:1), (4R)- is a high-purity, non-proteinogenic amino acid derivative with a defined stereochemistry, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized proline scaffold essential for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other bioactive compounds where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly protease inhibitors and other targeted therapies.
• Peptide Chemistry: Used to introduce constrained, hydroxylated proline analogs into peptide chains to modulate biological activity, stability, and conformation.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Biochemical Research: Serves as a standard or reagent in studies of collagen structure, enzyme-substrate interactions, and metabolic pathways involving hydroxyproline.
• Agrochemical Development: Potential use in creating chiral active ingredients for crop protection agents with improved efficacy and environmental profile.

Basic Information

Product Name	D-Proline, 4-Hydroxy-, Methyl Ester, Hydrochloride (1:1), (4R)-
CAS No.	114676-59-4
Molecular Formula	C6H11NO3 · HCl
Molecular Weight	197.62 g/mol
Synonyms	(4R)-4-Hydroxy-D-proline methyl ester hydrochloride; Methyl (4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride; D-4-Hydroxyproline methyl ester HCl; (2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid methyl ester hydrochloride; trans-4-Hydroxy-D-proline methyl ester hydrochloride; HYP(Me)-OH·HCl; (R,R)-HOPM·HCl
EINECS	Contact for details

Quality Control

Our D-Proline, 4-Hydroxy-, Methyl Ester, Hydrochloride (1:1), (4R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.