Description

(4Ar,7S,8R,8Ar)-5-Benzyl-2,2-Dimethylhexahydro-4H-[1,3]Dioxino[5,4-B]Pyridine-7,8-Diol CAS NO 114040-86-7 is a complex, stereochemically defined heterocyclic compound featuring a fused dioxino-pyridine core structure. This compound is of significant interest as a key chiral intermediate or building block in advanced organic synthesis, particularly for the development of pharmaceuticals and fine chemicals. It is primarily sought by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and other high-value specialty molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of potential drug candidates, especially those targeting neurological or metabolic pathways.
• Asymmetric Catalysis Research: Used as a ligand precursor or a model substrate in the development and study of new asymmetric catalytic reactions.
• Medicinal Chemistry: Employed as a core scaffold for constructing combinatorial libraries to explore structure-activity relationships (SAR) in drug discovery programs.
• Process Chemistry Development: Acts as a benchmark compound for optimizing synthetic routes, scaling up production, and developing robust purification protocols for complex molecules.
• Academic Research: Utilized in university and institutional labs for studies in synthetic methodology, total synthesis of natural products, and mechanistic investigations.
• Fine Chemical Production: Incorporated into the manufacture of specialty chemicals requiring high stereochemical purity and complex molecular architecture.

Basic Information

Product Name	(4Ar,7S,8R,8Ar)-5-Benzyl-2,2-Dimethylhexahydro-4H-[1,3]Dioxino[5,4-B]Pyridine-7,8-Diol
CAS No.	114040-86-7
Molecular Formula	C17H23NO4
Molecular Weight	305.37 g/mol
Synonyms	5-Benzyl-2,2-dimethylhexahydro-4H-[1,3]dioxino[5,4-b]pyridine-7,8-diol; (4aR,7S,8R,8aR)-5-Benzyl-2,2-dimethylhexahydro-4H-[1,3]dioxino[5,4-b]pyridine-7,8-diol; Hexahydro-5-benzyl-2,2-dimethyl-4H-[1,3]dioxino[5,4-b]pyridine-7,8-diol; Dioxinopyridine diol derivative; CAS 114040-86-7
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols. Each batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure high chemical and stereochemical purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture uptake, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.