Description

(2R,3R)-α2,α2,α3,α3-Tetraphenyl-1,4-Dioxaspiro[4.5]Decane-2,3-Dimethanol is a high-value, stereochemically defined chiral building block and ligand precursor. This compound matters for its role in asymmetric synthesis, where it serves as a key intermediate for constructing complex molecules with precise three-dimensional control. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Asymmetric Catalysis: As a precursor for chiral ligands used in transition metal-catalyzed reactions such as hydrogenation, epoxidation, and cross-coupling.
• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of chiral drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• Agrochemical Synthesis: Used in the research and development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science Research: Employed in the synthesis of chiral polymers, liquid crystals, and other functional materials with specific optical properties.
• Academic & Process Chemistry: A valuable tool for methodological development in organic synthesis and for scaling up chiral processes.

Basic Information

Product Name	(2R,3R)-α2,α2,α3,α3-Tetraphenyl-1,4-Dioxaspiro[4.5]Decane-2,3-Dimethanol
CAS No.	114026-76-5
Molecular Formula	C34H34O4
Molecular Weight	506.63 g/mol
Synonyms	(2R,3R)-2,3-Bis(hydroxymethyl)-2,3,5,5-tetraphenyl-1,4-dioxaspiro[4.5]decane; (2R,3R)-Tetraphenyl-1,4-dioxaspiro[4.5]decane-2,3-dimethanol; (R,R)-Tetraphenyl-Dioxaspirodecane-dimethanol; Chiral Spiroketal Diol; (R,R)-TADDOL Derivative; (2R,3R)-TADDOL Precursor; (2R,3R)-2,2,3,3-Tetraphenyl-1,4-dioxaspiro[4.5]decane-2,3-dimethanol
EINECS	Contact for details

Quality Control

Our (2R,3R)-α2,α2,α3,α3-Tetraphenyl-1,4-Dioxaspiro[4.5]Decane-2,3-Dimethanol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high enantiomeric excess (ee) and chemical purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with full chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.