Description

(S)-(+)-1,4-Dioxaspiro[4.5]Decane-2-Methanol is a high-value, chiral building block and intermediate of significant importance in advanced organic synthesis. Its spirocyclic acetal-protected structure and defined stereochemistry make it a critical precursor for the production of complex, optically active molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical and fine chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, including antiviral agents, central nervous system (CNS) drugs, and other bioactive compounds requiring high stereochemical purity.
• Agrochemical Synthesis: Used in the development of enantiomerically pure pesticides, herbicides, and plant growth regulators where specific stereochemistry impacts biological activity.
• Fine Chemical Production: Serves as a versatile building block for creating specialty chemicals, flavors, fragrances, and advanced materials with tailored properties.
• Asymmetric Catalysis & Ligand Synthesis: Employed in the preparation of chiral ligands and catalysts used in enantioselective transformations.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and for exploring new synthetic routes in process chemistry.

Basic Information

Item	Details
Product Name	(S)-(+)-1,4-Dioxaspiro[4.5]Decane-2-Methanol
CAS No.	113889-80-8
Molecular Formula	C9H16O3
Molecular Weight	172.22 g/mol
Synonyms	(S)-1,4-Dioxaspiro[4.5]decan-2-ylmethanol; (S)-(+)-1,4-Dioxaspiro[4.5]decan-2-methanol; (S)-2-(Hydroxymethyl)-1,4-dioxaspiro[4.5]decane; (S)-Spiro[1,3-dioxolane-2,1'-cyclohexane]-2-methanol; (S)-Cyclohexanone ethylene ketal-2-methanol; (S)-2-Hydroxymethyl-1,4-dioxaspiro[4.5]decane; (S)-1,4-Dioxaspiro[4.5]decane-2-carbinol
EINECS	Contact for details

Quality Control

Our production of (S)-(+)-1,4-Dioxaspiro[4.5]Decane-2-Methanol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as chiral purity (enantiomeric excess), chemical assay, and impurity profiles. Our quality systems are designed to meet the rigorous demands of GMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.