Description

cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-Triazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl]Methyl-p-Toluenesulfonate CAS NO 113770-65-3 is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the antifungal and agrochemical sectors. Industrial-scale manufacturers and R&D facilities require this material for its precise chemical structure and reliable performance in multi-step synthetic pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent triazole-based antifungal APIs.
• Agrochemical Synthesis: Used in the manufacturing of advanced fungicides and plant protection agents.
• Chemical Research & Development: Serves as a versatile scaffold for developing new chemical entities in medicinal chemistry.
• Fine Chemical Production: Employed in the production of specialty chemicals requiring a specific stereochemical configuration.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.
• Academic Research: Used in university and institutional labs for studying structure-activity relationships and reaction mechanisms.

Basic Information

Product Name	cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-Triazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl]Methyl-p-Toluenesulfonate
CAS No.	113770-65-3
Molecular Formula	C21H20Cl2N3O5S
Molecular Weight	481.37 g/mol
Synonyms	cis-1-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethyl 4-methylbenzenesulfonate acetal; cis-Tolylsulfonate derivative of a triazole dioxolane; (1R-cis)-4-[[(4-Methylphenyl)sulfonyl]oxy]methyl]-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane; cis-1,3-Dioxolan-4-ylmethyl p-toluenesulfonate derivative; Intermediate for Tebuconazole/Myclobutanil synthesis; cis-Configured triazole tosylate; 4-[[(4-Methylphenyl)sulfonyl]oxy]methyl]-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane (cis isomer)
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Quality Control

Our cis-[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-Triazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl]Methyl-p-Toluenesulfonate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm the cis-isomeric configuration, ensuring compliance with stringent industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Isomeric Purity (cis-isomer, HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.