Description

Boc-D-Arg-OH HCl H2O is a protected derivative of the non-natural enantiomer of the amino acid arginine, supplied as a hydrochloride salt hydrate. This high-purity building block is essential for the synthesis of peptides with enhanced metabolic stability and specific biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, drug discovery, and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of D-arginine into custom peptide sequences.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, including enzyme inhibitors, receptor agonists/antagonists, and antimicrobial peptides.
• Bioconjugation: Serves as a component for creating peptide tags or linkers in antibody-drug conjugates (ADCs) and other bioconjugates.
• Biochemical Tool Development: Employed in the synthesis of substrates, probes, and standards for enzymatic assays and diagnostic applications.
• Cosmeceutical Peptides: A raw material for synthesizing bioactive peptides used in advanced skincare and cosmetic formulations.

Basic Information

Product Name	Boc-D-Arg-OH HCl H2O
CAS No.	113712-06-4
Molecular Formula	C₁₁H₂₃ClN₄O₅ • xH₂O
Molecular Weight	322.78 (Anhydrous HCl salt)
Synonyms	N-α-(tert-Butoxycarbonyl)-D-arginine hydrochloride hydrate; Boc-D-Arginine hydrochloride hydrate; (R)-2-((tert-Butoxycarbonyl)amino)-5-guanidinopentanoic acid hydrochloride hydrate; D-Boc-Arg-OH • HCl • H₂O; Boc-D-Arg(Tos)-OH • HCl (common precursor); N-Boc-D-arginine HCl hydrate; tert-Butyloxycarbonyl-D-arginine hydrochloride hydrate
EINECS	Contact for details

Quality Control

Our Boc-D-Arg-OH HCl H2O is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation by IR and NMR. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤6.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.