Description

2,4-Difluoro-5-Nitrophenol is a versatile fluorinated aromatic building block, distinguished by its unique combination of electron-withdrawing nitro and hydroxyl groups on a difluorinated benzene ring. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its fluorine atoms enhance metabolic stability and bioavailability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders and anti-infectives.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, enhancing their thermal stability and optical properties.
• Polymer Modification: Employed to introduce fluorine groups into polymer chains, improving chemical resistance and surface properties of high-performance plastics.
• Dye & Pigment Intermediate: Utilized in the production of specialized fluorinated dyes and pigments for high-value applications.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.

Basic Information

Product Name	2,4-Difluoro-5-Nitrophenol
CAS No.	113512-57-5
Molecular Formula	C6H3F2NO3
Molecular Weight	175.09 g/mol
Synonyms	5-Nitro-2,4-difluorophenol; 2,4-Difluoro-5-nitro-1-hydroxybenzene; 1-Hydroxy-2,4-difluoro-5-nitrobenzene; Phenol, 2,4-difluoro-5-nitro-; 2,4-DF-5-NP; 2,4-Difluoro-5-nitrophenol (DFNP)
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-5-Nitrophenol is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure supply chain transparency and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request and are aligned with standard industry practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.