Description

Linopirdine Dihydrochloride is a high-purity, small molecule compound of significant interest in neurological and pharmacological research. This product is valued for its role as a potent and selective inhibitor of neuronal potassium channels, which is critical for studying synaptic transmission and cognitive function. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on neuroscience and drug discovery for cognitive disorders.

Application

• Neuroscience Research: As a key pharmacological tool for investigating the modulation of potassium currents (IK(M)) in neuronal cells and brain slices.
• Cognitive Disorder Studies: Used in preclinical research models to explore potential mechanisms for enhancing cognitive performance and treating conditions like Alzheimer's disease.
• Drug Discovery & Development: Serves as a reference standard or active compound in high-throughput screening and lead optimization programs targeting ion channels.
• Biochemical Assays: Employed in in vitro studies to understand synaptic plasticity, neurotransmitter release, and cellular excitability.
• Academic & Clinical Research: A critical reagent for university labs and clinical research facilities studying fundamental neurophysiology and potential therapeutic interventions.

Basic Information

Product Name	Linopirdine Dihydrochloride
CAS No.	113168-57-3
Molecular Formula	C16H20Cl2N2O
Molecular Weight	327.25 g/mol
Synonyms	Linopirdine HCl; DUP 996; DUP-996; 3,3-Bis(4-pyridinylmethyl)-1(3H)-isobenzofuranone dihydrochloride; Aviva's Linopirdine Dihydrochloride; 1(3H)-Isobenzofuranone, 3,3-bis(4-pyridinylmethyl)-, dihydrochloride
EINECS	Contact for details

Quality Control

Our Linopirdine Dihydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.