Description

(4S,5S)-2-Chloro-4,5-Dime.-1,3,2-Dioxa- Phospholane 2-Oxide is a high-value, stereochemically defined organophosphorus compound, specifically a chlorophosphite derivative. It serves as a critical chiral building block and ligand precursor in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. This product is essential for R&D and manufacturing chemists in the pharmaceutical, agrochemical, and advanced material sectors who require precise stereochemical control.

Application

• Asymmetric Catalysis: As a precursor for chiral phosphite and phosphoramidite ligands used in transition metal-catalyzed reactions like hydrogenation and hydroformylation.
• Pharmaceutical Intermediate: In the synthesis of active pharmaceutical ingredients (APIs) where stereocenters are crucial for biological activity.
• Agrochemical Synthesis: For creating enantiomerically pure herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Chiral Auxiliary: Employed in stoichiometric asymmetric transformations to induce chirality in target molecules.
• Material Science: As a monomer or modifying agent for polymers with specific optical or electronic properties.
• Academic & Industrial Research: A valuable tool for developing new synthetic methodologies and exploring novel catalytic systems.

Basic Information

Item	Details
Product Name	(4S,5S)-2-Chloro-4,5-Dime.-1,3,2-Dioxa- Phospholane 2-Oxide
CAS No.	112966-13-9
Molecular Formula	C4H8ClO3P
Molecular Weight	170.53 g/mol
Synonyms	(4S,5S)-2-Chloro-4,5-dimethyl-1,3,2-dioxaphospholane 2-oxide; (4S,5S)-4,5-Dimethyl-2-chloro-1,3,2-dioxaphospholane 2-oxide; (S,S)-2-Chloro-4,5-dimethyl-1,3,2-dioxaphospholane 2-oxide; Chloro((4S,5S)-4,5-dimethyl-1,3,2-dioxaphospholan-2-yl)oxidane; Dioxaphospholane oxide derivative; Chiral chlorophosphite; (S,S)-Dioxyphospholane chloride
EINECS	Contact for details

Quality Control

Our (4S,5S)-2-Chloro-4,5-Dime.-1,3,2-Dioxa- Phospholane 2-Oxide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure high chemical and enantiomeric purity suitable for sensitive asymmetric synthesis. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.