Description

Fmoc-D-Met-Oh CAS NO 112833-40-6 is a high-purity, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for introducing the D-isomer of methionine into peptide chains, enabling the creation of novel peptides with enhanced metabolic stability and unique biological properties. It is an essential building block for pharmaceutical R&D, particularly in the development of therapeutic peptides, diagnostic agents, and biochemical research tools.

Application

• Pharmaceutical Peptide Synthesis: A key protected amino acid for the automated synthesis of therapeutic peptides containing D-methionine residues.
• Research & Development: Used in academic and industrial labs to study peptide structure-activity relationships (SAR) and to create peptide libraries for screening.
• Bioconjugation: Serves as a precursor for creating peptide-based conjugates for targeted drug delivery and diagnostic imaging.
• Antibiotic & Antiviral Peptide Development: Incorporated into novel peptide sequences designed to mimic natural antimicrobial peptides with improved stability.
• Enzyme Substrate & Inhibitor Design: Used to synthesize specific peptide substrates or inhibitors for proteases and other enzymes.
• Material Science: Employed in the synthesis of peptide-based biomaterials and hydrogels.

Basic Information

Product Name	Fmoc-D-Met-Oh
CAS No.	112833-40-6
Molecular Formula	C₂₀H₂₁NO₄S
Molecular Weight	371.45 g/mol
Synonyms	Fmoc-D-methionine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-methionine; D-Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-D-Met; Fmoc-D-Methionine-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylthio)butanoic acid; N-Fmoc-D-methionine; D-Fmoc-Methionine
EINECS	Contact for details

Quality Control

Our Fmoc-D-Met-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥98.5% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP guidelines for pharmaceutical intermediates, and our quality protocols are designed to meet the stringent requirements of advanced peptide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.