Description

(S)-2-((1R,3As,7Ar,E)-4-((E)-2-((S)-5-((tert-Butyldimethylsilyl)Oxy)-2-Methylenecyclohexylidene)Ethylidene)-7A-Methyloctahydro-1H-Inden-1-Yl)Propanal is a sophisticated, high-purity chiral intermediate featuring a complex steroidal-like framework. This compound is of significant value in advanced organic synthesis, particularly for constructing molecules with precise three-dimensional architecture. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel steroid analogs and other complex therapeutic agents.
• Agrochemical Research: Used in the development of new-generation pesticides and plant growth regulators requiring specific stereochemistry.
• Asymmetric Synthesis: Serves as a key starting material or advanced intermediate in catalytic asymmetric reactions and total synthesis projects.
• Academic & Industrial R&D: Employed in chemical biology and medicinal chemistry research to explore structure-activity relationships (SAR).
• Process Chemistry: Used for scaling up synthetic routes in pilot plants and for optimizing manufacturing processes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(S)-2-((1R,3As,7Ar,E)-4-((E)-2-((S)-5-((tert-Butyldimethylsilyl)Oxy)-2-Methylenecyclohexylidene)Ethylidene)-7A-Methyloctahydro-1H-Inden-1-Yl)Propanal
CAS No.	112828-12-3
Molecular Formula	C28H46O2Si
Molecular Weight	442.76 g/mol
Synonyms	(S)-2-[(1R,3aS,7aR,E)-4-[(E)-2-[(S)-5-[(tert-Butyldimethylsilyl)oxy]-2-methylenecyclohexylidene]ethylidene]-7a-methyloctahydro-1H-inden-1-yl]propanal; (22E,24S)-Ergosta-5,7,22-trien-3β-ol TBDMS ether derivative precursor; Steroidal TBDMS aldehyde intermediate; 3-[(1R,3aS,7aR)-1-[(2S)-2-Formylpropyl]-7a-methyl-4-[(1E)-2-[(5S)-5-[[tert-butyl(dimethyl)silyl]oxy]-2-methylidenecyclohexylidene]ethylidene]-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propanal (IUPAC); TBS-protected steroidal aldehyde; CAS 112828-12-3.
EINECS	Contact for details

Quality Control

Our (S)-2-((1R,3As,7Ar,E)-4-((E)-2-((S)-5-((tert-Butyldimethylsilyl)Oxy)-2-Methylenecyclohexylidene)Ethylidene)-7A-Methyloctahydro-1H-Inden-1-Yl)Propanal is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from fluoride sources and strong alkali.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.