Description

1-Cyclopropyl-4-Oxo-6,7-Difluoro-8-Methyl-Quinolin is a high-purity, advanced pharmaceutical intermediate belonging to the fluoroquinolone class of compounds. This specialized chemical is critical for the research and development of next-generation antibacterial agents, offering a key structural motif for creating potent active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) focused on antimicrobial drug discovery and synthesis.

Application

• Pharmaceutical Intermediate: Serves as a core building block in the synthesis of novel fluoroquinolone antibiotic candidates.
• Antimicrobial Research: Used in biological and pharmacological studies to investigate structure-activity relationships (SAR) against resistant bacterial strains.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating complex, fluorinated heterocyclic molecules.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the scale-up and production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional laboratories for medicinal chemistry projects and the development of new synthetic methodologies.

Basic Information

Product Name	1-Cyclopropyl-4-Oxo-6,7-Difluoro-8-Methyl-Quinolin
CAS No.	112822-91-0
Molecular Formula	C₁₄H₁₁F₂NO
Molecular Weight	247.24 g/mol
Synonyms	1-Cyclopropyl-6,7-difluoro-8-methyl-4-quinolone; 6,7-Difluoro-8-methyl-1-cyclopropyl-4-quinolone; 1-Cyclopropyl-6,7-difluoro-8-methyl-4(1H)-quinolinone; 8-Methyl-1-cyclopropyl-6,7-difluoro-4-quinolone; 4-Quinolone, 1-cyclopropyl-6,7-difluoro-8-methyl-; Fluoroquinolone Intermediate FQ-8M
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-4-Oxo-6,7-Difluoro-8-Methyl-Quinolin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.