Description

(4S,5R)-(+)-1,5-Dimethyl-4-Phenyl-2-Imidazolidinone is a high-value, enantiomerically pure chiral auxiliary and organocatalyst. This compound matters for its critical role in facilitating asymmetric synthesis, enabling the production of single-enantiomer intermediates with high stereoselectivity. Pharmaceutical R&D laboratories and fine chemical manufacturers need it for developing active pharmaceutical ingredients (APIs), agrochemicals, and other specialty chemicals where precise stereochemistry is essential.

Application

• As a chiral auxiliary in asymmetric aldol, alkylation, and Diels-Alder reactions.
• As an organocatalyst for enantioselective synthesis in pharmaceutical research.
• For the preparation of stereochemically defined intermediates in Active Pharmaceutical Ingredient (API) development.
• In the synthesis of complex natural products and agrochemicals requiring specific chiral centers.
• As a key reagent in methodological studies for developing new asymmetric transformations.
• For use in process chemistry to improve the yield and purity of chiral target molecules.

Basic Information

Product Name	(4S,5R)-(+)-1,5-Dimethyl-4-Phenyl-2-Imidazolidinone
CAS No.	112791-04-5
Molecular Formula	C11H14N2O
Molecular Weight	190.24 g/mol
Synonyms	(4S,5R)-1,5-Dimethyl-4-phenylimidazolidin-2-one; (4S,5R)-(+)-1,5-Dimethyl-4-phenyl-2-imidazolidinone; (+)-1,5-Dimethyl-4-phenyl-2-imidazolidinone; (S,R)-1,5-Dimethyl-4-phenyl-2-imidazolidinone; MacMillan's First Generation Imidazolidinone Catalyst; Organocatalyst; Chiral Auxiliary
EINECS	Contact for details

Quality Control

Our (4S,5R)-(+)-1,5-Dimethyl-4-Phenyl-2-Imidazolidinone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high enantiomeric excess (ee) and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with full characterization data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Specific Rotation [α]D20	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.