Description

(2E)-2-(4-Ethoxybenzylidene)-1-Azabicyclo[2.2.2]Octan-3-One is a sophisticated organic compound featuring a quinuclidine core, a structural motif of significant interest in medicinal chemistry. This compound serves as a key advanced intermediate for the synthesis of complex pharmaceutical agents, particularly those targeting the central nervous system. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potential drug candidates, especially those with neurological activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize biological activity profiles.
• Chemical Synthesis: Serves as a versatile precursor for creating libraries of complex heterocyclic compounds for high-throughput screening.
• Academic Research: Employed in university and institutional labs for studying synthetic methodologies and reaction mechanisms involving quinuclidine derivatives.
• Process Development: Utilized in scaling up synthetic routes from laboratory to pilot plant scale for new active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	(2E)-2-(4-Ethoxybenzylidene)-1-Azabicyclo[2.2.2]Octan-3-One
CAS No.	112611-38-8
Molecular Formula	C₁₆H₁₉NO₂
Molecular Weight	257.33 g/mol
Synonyms	(E)-2-(4-Ethoxybenzylidene)quinuclidin-3-one; 2-[(E)-(4-Ethoxyphenyl)methylene]-1-azabicyclo[2.2.2]octan-3-one; 2-(4-Ethoxybenzylidene)-3-quinuclidinone; Quinuclidin-3-one, 2-[(E)-(4-ethoxyphenyl)methylene]-; 1-Azabicyclo[2.2.2]octan-3-one, 2-[(E)-(4-ethoxyphenyl)methylene]-
EINECS	Contact for details

Quality Control

Our production of (2E)-2-(4-Ethoxybenzylidene)-1-Azabicyclo[2.2.2]Octan-3-One adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development and commercial projects with specifications that can meet the requirements of cGMP and ICH Q7 guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.