Description

(S)-tert-Leucinol is a high-value, non-natural chiral amino alcohol building block, essential for the synthesis of complex molecules with precise stereochemistry. Its rigid tertiary butyl group provides exceptional steric bulk, making it a critical component for inducing high enantioselectivity in asymmetric catalysis and for constructing conformationally constrained pharmacophores. This compound is indispensable for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing advanced active ingredients and chiral ligands.

Application

• Pharmaceutical Intermediates: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Asymmetric Catalysis: Used as a precursor for chiral ligands (e.g., oxazolidinones, phosphines) and organocatalysts in enantioselective synthesis.
• Agrochemicals: Building block for chiral herbicides, fungicides, and plant growth regulators requiring specific stereochemistry for efficacy.
• Peptidomimetics: Incorporation into peptide backbones to enhance metabolic stability and modulate biological activity.
• Material Science: Monomer for chiral polymers and liquid crystals with specialized optical properties.
• Chemical Biology: Tool compound for probing enzyme active sites and studying protein-ligand interactions.

Basic Information

Product Name	(S)-tert-Leucinol
CAS No.	112245-13-3
Molecular Formula	C6H15NO
Molecular Weight	117.19 g/mol
Synonyms	(S)-2-Amino-3,3-dimethylbutan-1-ol; (S)-2-Amino-3,3-dimethyl-1-butanol; (S)-tert-Butylglycinol; (S)-2-Amino-1-hydroxy-3,3-dimethylbutane; (S)-Amino-tert-leucinol; (S)-H-tert-Leu-ol; (S)-2-Amino-3,3-dimethylbutanol; (S)-2-Aminoneopentanol
EINECS	Contact for details

Quality Control

Our (S)-tert-Leucinol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including chiral purity (enantiomeric excess) verification, to support your critical R&D and cGMP manufacturing processes. Certificates of Analysis (COA) with detailed specifications from HPLC, GC, and NMR are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	72 - 76 °C
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.