Description

(S)-(-)-3,3'-Dibromo-1,1'-Bi-2-Naphthol CAS NO 111795-43-8 is a high-purity, chiral binaphthol derivative, specifically the (S)-enantiomer, functionalized with bromine atoms at the 3,3' positions. This compound is a crucial chiral ligand and catalyst precursor in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by research institutions, pharmaceutical R&D labs, and specialty chemical manufacturers engaged in developing novel therapeutic agents and high-value intermediates.

Application

• Asymmetric Catalysis: As a chiral ligand for transition metals (e.g., titanium, zinc) in enantioselective carbon-carbon bond-forming reactions like the Henry reaction or alkylation.
• Pharmaceutical Intermediate: A key building block in the synthesis of chiral active pharmaceutical ingredients (APIs) and complex natural products.
• Chiral Resolution Agent: Used to separate enantiomers of racemic mixtures through diastereomeric salt formation or coordination.
• Material Science Research: A precursor for chiral polymers, liquid crystals, and other advanced functional materials with optical activity.
• Organic Synthesis Reagent: Employed in the preparation of other chiral auxiliaries and organocatalysts.

Basic Information

Product Name	(S)-(-)-3,3'-Dibromo-1,1'-Bi-2-Naphthol
CAS No.	111795-43-8
Molecular Formula	C₂₀H₁₂Br₂O₂
Molecular Weight	452.12 g/mol
Synonyms	(S)-(-)-3,3'-Dibromo-1,1'-bi-2-naphthol; (S)-3,3'-Dibromo-1,1'-binaphthyl-2,2'-diol; (S)-3,3'-Dibromo-BINOL; (S)-(-)-3,3'-Dibromo-2,2'-dihydroxy-1,1'-binaphthyl; (S)-Dibromobinaphthol; (S)-DB-BINOL; (S)-3,3'-Dibromobinaphthol; (S)-3,3'-Dibromo-1,1'-binaphthalene-2,2'-diol
EINECS	Contact for details

Quality Control

Our (S)-(-)-3,3'-Dibromo-1,1'-Bi-2-Naphthol is manufactured under strict quality protocols to ensure high enantiomeric purity and chemical consistency. Each batch undergoes comprehensive analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.