Description

3-(Methylsulfonyl)-1-Propyne is a versatile sulfur-containing alkyne building block, recognized for its unique reactivity profile. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing sulfonyl and alkyne functionalities for targeted drug discovery.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides, leveraging its reactive alkyne group for structural diversification.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced materials with tailored properties.
• Organic Synthesis Reagent: Employed in click chemistry (e.g., copper-catalyzed azide-alkyne cycloaddition) and other coupling reactions to introduce functionalized propynyl groups.
• Ligand and Catalyst Development: Utilized as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Life Sciences & Bioconjugation: Acts as a reactive handle for labeling biomolecules (proteins, nucleic acids) in probe and diagnostic agent development.

Basic Information

Product Name	3-(Methylsulfonyl)-1-Propyne
CAS No.	111247-76-8
Molecular Formula	C₄H₆O₂S
Molecular Weight	118.15 g/mol
Synonyms	Methyl Propargyl Sulfone; 1-(Methylsulfonyl)-2-propyne; Propargyl Methyl Sulfone; 3-(Methanesulfonyl)prop-1-yne; 2-Propynyl Methyl Sulfone; Methyl 2-Propynyl Sulfone; 1-Methylsulfonyl-2-propyne
EINECS	Contact for details

Quality Control

Our 3-(Methylsulfonyl)-1-Propyne is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.