Description

1-((2-Chloro-6,7-Dimethoxy-4-Quinazolinyl)Oxy)-3-((1-Methylethyl)Amino )-2-Propanol is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of targeted therapeutic agents, particularly within the field of kinase inhibition. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel drug candidates. The material is supplied with a focus on batch-to-batch consistency and reliable supply chain integrity for critical development projects.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel quinazoline-based kinase inhibitors for oncology research.
• Biochemical Research: Used as a reference standard and probe molecule in enzymatic assays and structure-activity relationship (SAR) studies.
• Preclinical Development: Serves as a key starting material (KSM) or advanced intermediate in the scale-up and process development of potential drug substances.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and GMP production campaigns.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry programs focused on signal transduction pathways.

Basic Information

Product Name	1-((2-Chloro-6,7-Dimethoxy-4-Quinazolinyl)Oxy)-3-((1-Methylethyl)Amino )-2-Propanol
CAS No.	111218-76-9
Molecular Formula	C₁₆H₂₂ClN₃O₄
Molecular Weight	355.82 g/mol
Synonyms	2-Chloro-6,7-dimethoxy-4-[(2-hydroxy-3-[(1-methylethyl)amino]propoxy]quinazoline; (RS)-1-[(2-Chloro-6,7-dimethoxyquinazolin-4-yl)oxy]-3-(isopropylamino)propan-2-ol; Isopropylamino-propanol quinazoline derivative; Quinazoline kinase inhibitor intermediate; 4-[(2-Hydroxy-3-(isopropylamino)propoxy]-2-chloro-6,7-dimethoxyquinazoline; ZD-6474 Intermediate (Vandetanib-related); N-Isopropyl-1-[(2-chloro-6,7-dimethoxy-4-quinazolinyl)oxy]-3-amino-2-propanol
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure it meets the exacting requirements of pharmaceutical development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Quality systems are designed to support development work under ISO 9001 guidelines, with the capability to align with GMP standards for critical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.