Description

[4-(4-Amino-6-Bromo-2-Quinazolinyl)-1-Piperazinyl]-2-Furanylmethanone is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of novel, targeted therapeutic agents, particularly in oncology research. Pharmaceutical R&D laboratories and fine chemical manufacturers need this precise intermediate to develop next-generation drug candidates with improved efficacy and selectivity.

Application

This specialized intermediate serves as a crucial precursor in several high-value chemical synthesis pathways. Its primary applications include:

• Pharmaceutical Intermediate: Serves as a core scaffold for the development of kinase inhibitors and other targeted cancer therapies.
• Organic Synthesis Building Block: Used in research-scale and pilot-scale synthesis of complex quinazoline and piperazine derivatives.
• Biochemical Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of active pharmaceutical ingredients (APIs) under cGMP.
• Academic Research: Utilized in university and institutional labs for pioneering studies in heterocyclic chemistry and drug discovery.

Basic Information

Product Name	[4-(4-Amino-6-Bromo-2-Quinazolinyl)-1-Piperazinyl]-2-Furanylmethanone
CAS No.	111218-69-0
Molecular Formula	C₁₇H₁₅BrN₆O₂
Molecular Weight	415.25 g/mol
Synonyms	4-(4-Amino-6-bromoquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)methanone; 2-Furyl[4-(4-amino-6-bromo-2-quinazolinyl)-1-piperazinyl]methanone; 111218-69-0; (Furan-2-yl)[4-(4-amino-6-bromo-2-quinazolinyl)piperazin-1-yl]methanone; 4-Amino-6-bromo-2-(4-(2-furoyl)piperazin-1-yl)quinazoline
EINECS	Contact for details

Quality Control

Our [4-(4-Amino-6-Bromo-2-Quinazolinyl)-1-Piperazinyl]-2-Furanylmethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and cGMP intermediate production. Certificates of Analysis (COA) with full chromatographic data are provided for every shipment, and we support vendor qualification audits.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and away from incompatible materials. For long-term storage, consider under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.