Description

8-Ethoxy-4-Oxo-1,4-Dihydro-Quinoline-3-Carboxylic Acid is a high-purity, synthetically derived quinoline derivative that serves as a critical advanced pharmaceutical intermediate. Its core value lies in its role as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly within the quinolone and fluoroquinolone antibiotic classes. This compound is essential for research and development chemists, process development scientists, and manufacturers in the global pharmaceutical and fine chemical industries seeking to develop new therapeutic agents or optimize synthetic routes.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel quinolone and fluoroquinolone antibiotic candidates, enabling the exploration of new antimicrobial agents.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and the development of new chemical entities targeting bacterial infections.
• Process Chemistry: Employed in the scale-up and optimization of API manufacturing processes, where consistent quality and purity are paramount for regulatory filings.
• Fine Chemical Synthesis: Serves as a specialized building block for creating complex organic molecules with potential biological activity beyond antibiotics.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) engaged in producing clinical trial materials or commercial APIs for global markets.

Basic Information

Product Name	8-Ethoxy-4-Oxo-1,4-Dihydro-Quinoline-3-Carboxylic Acid
CAS No.	111185-99-0
Molecular Formula	C₁₃H₁₁NO₄
Molecular Weight	245.23 g/mol
Synonyms	8-Ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 8-Ethoxy-4-hydroxyquinoline-3-carboxylic acid; 3-Quinolinecarboxylic acid, 1,4-dihydro-8-ethoxy-4-oxo-; 8-Ethoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 8-Ethoxy-4-oxo-1H-quinoline-3-carboxylic acid; 8-Ethoxy-4-oxoquinoline-3-carboxylic acid; 8-Ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 111185-99-0)
EINECS	Contact for details

Quality Control

Our 8-Ethoxy-4-Oxo-1,4-Dihydro-Quinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.