Description

3-(1H-Imidazol-4-Yl)-Propylamine Hcl is a high-purity organic salt derivative of histamine, featuring a propylamine linker to the imidazole ring. This compound is a critical building block and pharmacological research intermediate for the development of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams focused on histamine receptor modulators and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of histamine H3 and H4 receptor ligands for central nervous system and inflammatory disorder research.
• Bioconjugation Reagent: Used to introduce imidazole functionality for protein labeling or surface modification due to its amine-reactive group.
• Chemical Biology Probe: Serves as a core structure for developing fluorescent or affinity probes to study histaminergic pathways.
• Catalyst Ligand Synthesis: Employed in the preparation of specialized ligands for metal-complex catalysts in asymmetric synthesis.
• Peptidomimetics: Incorporated into peptide analogs to mimic histidine residues or introduce specific binding motifs.
• Academic & Contract Research: Essential for medicinal chemistry programs in academic institutions and CROs (Contract Research Organizations).

Basic Information

Product Name	3-(1H-Imidazol-4-Yl)-Propylamine Hcl
CAS No.	111016-57-0
Molecular Formula	C6H12ClN3
Molecular Weight	161.63 g/mol
Synonyms	4-(3-Aminopropyl)imidazole hydrochloride; Histamine propylamine hydrochloride; 3-(1H-Imidazol-4-yl)propan-1-amine hydrochloride; 1H-Imidazole-4-propanamine, hydrochloride; 4-(3-Aminopropyl)-1H-imidazole hydrochloride; SKF-91488 (as dihydrochloride salt precursor); Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 3-(1H-Imidazol-4-Yl)-Propylamine Hcl is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.