Description

Alloc-L-Trp-Oh is a protected derivative of the essential amino acid L-Tryptophan, specifically featuring the Alloc (Allyloxycarbonyl) protecting group on the amine functionality. This compound is a critical building block in modern solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptide chains. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, peptidomimetics, and biochemical probes. Its high purity and reliable performance are essential for ensuring the fidelity and yield of target peptide sequences.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key intermediate for the incorporation of Tryptophan residues using Fmoc/t-Bu or Alloc-based strategies.
• Pharmaceutical Research: Used in the research and development of novel peptide-based drugs, hormones, and diagnostic agents.
• Bioconjugation: Acts as a precursor for creating labeled peptides or peptide-protein conjugates for biochemical studies.
• Combinatorial Chemistry: Employed in libraries for drug discovery to explore structure-activity relationships (SAR).
• Production of Custom Peptides: Essential for contract manufacturing organizations (CMOs) producing GMP and non-GMP peptides for clinical and commercial supply.
• Academic Research: Utilized in university and institutional labs for fundamental studies in biochemistry, molecular biology, and medicinal chemistry.

Basic Information

Product Name	Alloc-L-Trp-Oh
CAS No.	110637-46-2
Molecular Formula	C16H18N2O4
Molecular Weight	302.33 g/mol
Synonyms	N-Alloc-L-tryptophan; (S)-2-(((Allyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid; Allyl (S)-1-((allyloxy)carbonyl)-2-(1H-indol-3-yl)ethylcarbamate; Alloc-Trp-OH; Fmoc-L-Trp(Alloc)-OH (related protected form); N-α-Alloc-L-tryptophan; Allyloxycarbonyl-L-tryptophan; L-Tryptophan, N-[(allyloxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Alloc-L-Trp-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We support compliance with relevant guidelines for materials intended for research and non-GMP pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.