Description

Tirilazad CAS NO 110101-67-2 is a potent 21-aminosteroid compound, specifically a lazaroid, developed as a novel antioxidant and lipid peroxidation inhibitor. Its primary value lies in its neuroprotective properties, targeting the reduction of oxidative damage in cell membranes, which is a critical pathway in various injury models. This makes it a compound of significant interest for research and development within the pharmaceutical and life science sectors, particularly for studies in stroke, traumatic brain injury, and other neurological disorders.

Application

• Neuroprotection Research: A key investigational agent in preclinical and clinical studies for ischemic stroke and head trauma.
• Antioxidant Mechanism Studies: Used to investigate the role of lipid peroxidation and free radical damage in various disease models.
• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in API manufacturing.
• Biochemical Research: Employed in vitro and in vivo studies to understand cellular responses to oxidative stress.
• Drug Discovery & Development: A valuable tool compound for screening and validating new therapeutic targets related to oxidative damage.

Basic Information

Product Name	Tirilazad
CAS No.	110101-67-2
Molecular Formula	C33H44N2O3
Molecular Weight	516.72 g/mol
Synonyms	Tirilazad Mesylate; U-74006F; 21-[4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-16α-methylpregna-1,4,9(11)-triene-3,20-dione; Lazaroid; 21-Aminosteroid; Pregnatriene derivative; Antioxidant lazaroid
EINECS	Contact for details

Quality Control

Our Tirilazad is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR), and control of related substances and residual solvents. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.