Description

1,2-Dideoxy-3,4,5,6-Di-o-Isopropylidene-1,2-C-Methylene-1-Nitromannitol is a specialized, high-purity synthetic intermediate of significant interest in advanced organic synthesis. Its unique bicyclic, protected structure with a nitromethyl group makes it a valuable chiral building block for the construction of complex molecules. This compound is primarily sought after by research institutions and pharmaceutical development teams working on nucleoside analogs, carbohydrate-based therapeutics, and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Carbohydrate Chemistry Research: Serves as a protected, functionalized mannitol derivative for studying glycosylation reactions, enzyme inhibitors, and carbohydrate mimetics.
• Organic Synthesis Building Block: Utilized in the stereoselective synthesis of complex natural products and other high-value fine chemicals due to its defined stereochemistry.
• Methodology Development: Used in academic and industrial labs to develop new synthetic methodologies involving nitroalkanes and fused ring systems.
• Precursor to Biologically Active Molecules: Acts as a starting material for generating libraries of compounds for high-throughput screening in drug discovery campaigns.

Basic Information

Product Name	1,2-Dideoxy-3,4,5,6-Di-o-Isopropylidene-1,2-C-Methylene-1-Nitromannitol
CAS No.	110085-92-2
Molecular Formula	C13H19NO7
Molecular Weight	301.29 g/mol
Synonyms	1,2-Dideoxy-3,4:5,6-di-O-isopropylidene-1,2-C-methylene-1-nitromannitol; 1,2-Dideoxy-3,4:5,6-di-O-isopropylidene-1,2-C-methylene-D-mannitol-1-nitromethane; 1-Nitro-1,2-dideoxy-3,4:5,6-di-O-isopropylidene-1,2-C-methylene-D-mannitol; (3aR,4S,6R,6aR)-6-(Hydroxymethyl)-2,2-dimethyl-4-nitro-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxole-5,5(2H)-dicarbaldehyde; 1,2-Dideoxy-3,4-O-isopropylidene-1,2-C-methylene-1-nitromannitol 5,6-acetonide; D-Mannitol, 1,2-dideoxy-3,4:5,6-bis-O-(1-methylethylidene)-1,2-C-methylene-1-nitro-
EINECS	Contact for details

Quality Control

Our 1,2-Dideoxy-3,4,5,6-Di-o-Isopropylidene-1,2-C-Methylene-1-Nitromannitol is produced under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for demanding research applications. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.