Description

(+)-4,5-Bis[Hydroxy(Diphenyl)Methyl]-2-Methyl-2-Phenyl-1,3-Dioxolane is a high-value, chiral 1,3-dioxolane derivative characterized by its unique sterically hindered structure. This compound matters as a sophisticated chiral auxiliary and ligand in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures with high stereoselectivity.

Application

• As a chiral auxiliary in stereoselective organic synthesis, particularly for aldol and alkylation reactions.
• Utilized as a key ligand or precursor in the development of asymmetric catalysts for hydrogenation and carbon-carbon bond formation.
• Employed in pharmaceutical intermediate synthesis for active pharmaceutical ingredients (APIs) requiring specific chirality.
• Application in academic and industrial research for methodological development in asymmetric catalysis.
• Potential use as a building block for chiral stationary phases in chromatographic separation techniques.
• As a specialty fine chemical in the development of novel agrochemicals and performance materials.

Basic Information

Product Name	(+)-4,5-Bis[Hydroxy(Diphenyl)Methyl]-2-Methyl-2-Phenyl-1,3-Dioxolane
CAS No.	109306-21-0
Molecular Formula	C37H34O4
Molecular Weight	542.66 g/mol
Synonyms	(+)-TADDOL; (4R,5R)-4,5-Bis(diphenylhydroxymethyl)-2,2-dimethyl-1,3-dioxolane; (R,R)-TADDOL; TADDOL derivative; α,α,α',α'-Tetraaryl-1,3-dioxolane-4,5-dimethanol; 1,3-Dioxolane-4,5-dimethanol, 2,2-dimethyl-α,α,α',α'-tetraphenyl-, (4R,5R)-; (4R,5R)-2,2-Dimethyl-α,α,α',α'-tetraphenyl-1,3-dioxolane-4,5-dimethanol
EINECS	Contact for details

Quality Control

Our (+)-TADDOL is produced under strict quality protocols to ensure high chemical and chiral purity, critical for sensitive asymmetric applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and key physical parameters. We adhere to cGMP principles where applicable, and specifications can be tailored to meet specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect performance. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.