Description

4-n-Boc-4-n-Methyl-Aminopiperidine is a high-purity, protected piperidine derivative widely used as a critical building block in advanced organic synthesis. This compound is essential for the efficient construction of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Scaffold: Used to introduce the protected aminopiperidine moiety into lead compounds for structure-activity relationship (SAR) studies and optimization of drug-like properties.
• Peptidomimetic Synthesis: Serves as a constrained scaffold in the design and synthesis of peptidomimetics, which are crucial for developing stable and bioavailable therapeutic agents.
• Agrochemical Research: Employed as a building block in the development of novel herbicides, fungicides, and insecticides that require specific amine functionality.
• Ligand and Catalyst Preparation: Utilized in the preparation of specialized ligands for asymmetric catalysis or metal complexes used in cross-coupling reactions.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke intermediates for client projects.

Basic Information

Product Name	4-n-Boc-4-n-Methyl-Aminopiperidine
CAS No.	108612-54-0
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	1-Boc-4-(Methylamino)piperidine; tert-Butyl 4-(methylamino)piperidine-1-carboxylate; 4-(Methylamino)-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester; 1-N-Boc-4-N-Methylaminopiperidine; 4-(Methylamino)piperidine-1-carboxylic acid tert-butyl ester; N-Boc-4-(N-Methylamino)piperidine; 4-Methylaminopiperidine-1-carboxylic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our 4-n-Boc-4-n-Methyl-Aminopiperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity. We provide detailed Certificates of Analysis (COA) with every shipment, documenting critical parameters such as assay, impurity profile, and residual solvents. Our quality commitment supports applications requiring GMP-grade starting materials and ensures consistency for scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.