Description

Rel-(1R,2R)-2-Phenylcyclobutanecarboxylic Acid is a high-purity chiral cyclobutane derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate) and a versatile building block in asymmetric synthesis. Its defined stereochemistry is essential for constructing complex molecules with specific biological activity, making it invaluable for research and development. This compound is primarily targeted at the pharmaceutical, agrochemical, and specialty fine chemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis: A versatile precursor in stereoselective organic reactions, including cross-coupling and ring-opening transformations, to create complex molecular architectures.
• Agrochemical Research: Used in the development of new chiral pesticides and herbicides where specific stereochemistry influences efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a scaffold for creating novel chiral ligands and organocatalysts used in enantioselective catalysis.
• Academic & Industrial R&D: A valuable reference standard and starting material for methodological studies in synthetic organic and medicinal chemistry.
• Fine Chemical Production: Employed in the custom synthesis of high-value, specialty chemicals for electronics and material science applications.

Basic Information

Product Name	Rel-(1R,2R)-2-Phenylcyclobutanecarboxylic Acid
CAS No.	107841-64-5
Molecular Formula	C11H12O2
Molecular Weight	176.21 g/mol
Synonyms	(1R,2R)-rel-2-Phenylcyclobutanecarboxylic Acid; rel-(1R,2R)-2-Phenylcyclobutanecarboxylic Acid; 2-Phenylcyclobutanecarboxylic Acid, (1R,2R)-rel-; (1R,2R)-2-Phenyl-1-cyclobutanecarboxylic Acid; (±)-trans-2-Phenylcyclobutanecarboxylic Acid; trans-2-Phenylcyclobutanecarboxylic Acid (racemic); 2-Phenylcyclobutanecarboxylic Acid; Cyclobutanecarboxylic acid, 2-phenyl-, (1R,2R)-rel-
EINECS	Contact for details

Quality Control

Our Rel-(1R,2R)-2-Phenylcyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.