Description

1,3-Di-Boc-2-Methylisothiourea is a high-purity, protected isothiourea derivative widely used as a critical building block in organic synthesis. This compound is valued for its role in introducing the thiourea moiety under controlled conditions, enabling the synthesis of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of thiourea-containing drug candidates, including kinase inhibitors and antiviral agents.
• Peptide Mimetics & Conjugates: Used for the preparation of peptide isosteres and bioconjugates where a stable, protected thiourea linkage is required.
• Agrochemical Research: Serves as a precursor in the development of new herbicides and fungicides that incorporate thiourea functional groups.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Material Science: Acts as a monomer or cross-linking agent in the development of specialty polymers with unique thermal or chemical properties.
• Academic & Process R&D: A versatile building block for methodological development and scale-up synthesis in laboratory and pilot plant settings.

Basic Information

Product Name	1,3-Di-Boc-2-Methylisothiourea
CAS No.	107819-90-9
Molecular Formula	C13H24N2O4S
Molecular Weight	304.40 g/mol
Synonyms	1,3-Bis(tert-butoxycarbonyl)-2-methylisothiourea; 2-Methyl-1,3-bis[(2-methylpropan-2-yl)oxycarbonyl]isothiourea; Di-tert-butyl 2-methylisothioureidocarbonate; 1,3-Di-tert-butoxycarbonyl-2-methylisothiourea; 2-Methyl-1,3-di-Boc-isothiourea; N,N'-Di-Boc-2-methylisothiourea; 2-Methyl-1,3-bis(tert-butoxycarbonyl)isothiourea; 1,3-Di-Boc-2-methyl-2-thiopseudourea
EINECS	Contact for details

Quality Control

Our 1,3-Di-Boc-2-Methylisothiourea is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.