Description

Ethyl 6,8-Difluoro-4-Hydroxyquinoline-3-Carboxylate is a high-purity fluorinated quinoline derivative serving as a critical advanced pharmaceutical intermediate. This compound is valued for its precise molecular structure, which is essential for synthesizing active pharmaceutical ingredients (APIs) with targeted biological activity. It is primarily required by R&D laboratories and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel fluoroquinolone antibiotics and other bioactive molecules.
• Agrochemical Research: Used in developing advanced fungicides and herbicides that leverage the fluorinated quinoline scaffold.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization to create specialized chemical libraries.
• Material Science: Investigated for potential applications in creating organic electronic materials and fluorescent markers.
• Academic & Contract Research: Employed in university and CRO settings for medicinal chemistry programs and structure-activity relationship (SAR) studies.

Basic Information

Product Name	Ethyl 6,8-Difluoro-4-Hydroxyquinoline-3-Carboxylate
CAS No.	107555-38-4
Molecular Formula	C₁₂H₉F₂NO₃
Molecular Weight	253.20 g/mol
Synonyms	6,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester; Ethyl 6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate; 4-Hydroxy-6,8-difluoroquinoline-3-carboxylic Acid Ethyl Ester; 3-Quinolinecarboxylic acid, 6,8-difluoro-4-hydroxy-, ethyl ester; 6,8-Difluoro-4-hydroxy-3-quinolinecarboxylic acid ethyl ester; 1,4-Dihydro-6,8-difluoro-4-oxo-3-quinolinecarboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 6,8-Difluoro-4-Hydroxyquinoline-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.