Description

1 2:5 6-Di-o-Isopropylidene-D-Mannitol is a high-purity, protected derivative of D-mannitol, a key chiral building block in organic synthesis. This compound matters for its role as a versatile intermediate in the production of complex pharmaceuticals and fine chemicals, offering a rigid, defined stereochemistry for asymmetric synthesis. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of nucleoside analogs, antiviral drugs, and other active pharmaceutical ingredients (APIs).
• Asymmetric Catalyst Ligand Precursor: Used to develop chiral ligands for metal-catalyzed reactions, enabling the production of enantiomerically pure compounds.
• Fine Chemical Synthesis: Serves as a starting material or protected intermediate in the multi-step synthesis of complex natural products and specialty molecules.
• Agrochemical Research: Employed in the research and development of chiral pesticides and herbicides where specific stereochemistry is critical for activity.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and for exploring new synthetic pathways.

Basic Information

Product Name	1 2:5 6-Di-o-Isopropylidene-D-Mannitol
CAS No.	106571-12-4
Molecular Formula	C12H20O6
Molecular Weight	260.28 g/mol
Synonyms	1,2:5,6-Di-O-isopropylidene-D-mannitol; Diacetone-D-mannitol; D-Mannitol 1,2:5,6-di-O-isopropylidene acetal; 1,2:5,6-Di-O-(1-methylethylidene)-D-mannitol; (2R,3R)-2,3-Bis[(2R,3R)-2,2-dimethyl-1,3-dioxolan-4-yl]butane-1,4-diol; Isopropylidene-D-mannitol; D-Mannitol diacetonide
EINECS	Contact for details

Quality Control

Our 1 2:5 6-Di-o-Isopropylidene-D-Mannitol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and specific impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.