Description

Aminooxy-Peg4-Alcohol is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive aminooxy group and a terminal hydroxyl group. This compound is essential for creating stable oxime bonds with carbonyl-containing molecules, enabling precise bioconjugation and chemical modification. It is a critical reagent for researchers and manufacturers in biopharmaceutical development, proteomics, and advanced material science, where controlled linker chemistry is paramount.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of antibodies, proteins, or peptides to drugs, toxins, or fluorophores via oxime ligation.
• PEGylation Reagent: Introduction of a hydrophilic PEG spacer to enhance the solubility, stability, and pharmacokinetic properties of therapeutic molecules.
• Surface Functionalization: Modification of biosensor surfaces, nanoparticles, or microarrays for immobilizing biomolecules.
• Crosslinking Agent: Creating defined crosslinks between aldehydes or ketones in biomolecules for structural studies or hydrogel formation.
• Chemical Biology Probes: Synthesis of activity-based probes for labeling and studying carbonyl-containing metabolites or post-translational modifications.
• Polymer Chemistry: Serving as a functional initiator or monomer in the synthesis of smart polymers and functionalized nanomaterials.

Basic Information

Product Name	Aminooxy-Peg4-Alcohol
CAS No.	106492-60-8
Molecular Formula	C13H29NO7
Molecular Weight	311.37 g/mol
Synonyms	4-Aminooxybutyl-[1,4,7,10]tetraoxa-13-azatridecan-13-ol; 17-Amino-4,7,10,13-tetraoxa-16-azaheptadecan-1-ol; Aminooxy-PEG4-OH; O-(2-Aminooxyethyl)-O'-(2-hydroxyethyl)decaethylene glycol; Aminooxy-PEG4-alcohol; Aminooxy tetraethylene glycol alcohol; Hydroxyl-PEG4-aminooxy
EINECS	Contact for details

Quality Control

Our Aminooxy-Peg4-Alcohol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and absence of critical impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.