Description

2-Iododesmethylimipramine is a halogenated derivative of the tricyclic antidepressant desipramine, primarily utilized as a key intermediate in advanced pharmaceutical research and development. This compound is of significant value for medicinal chemists engaged in structure-activity relationship (SAR) studies and the synthesis of novel bioactive molecules targeting the central nervous system. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity building blocks for drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel tricyclic antidepressant analogs and other neuroactive compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of halogen substitution on pharmacological activity and receptor binding affinity.
• Biochemical Tool Compound: Serves as a labeled or modified ligand in neuroscience research for studying neurotransmitter transporters, particularly the norepinephrine transporter (NET).
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling in active pharmaceutical ingredient (API) manufacturing.
• Preclinical Development: Utilized in the early-stage development of potential therapeutic agents for psychiatric and neurological disorders.

Basic Information

Product Name	2-Iododesmethylimipramine
CAS No.	104880-94-6
Molecular Formula	C₁₈H₁₉IN₂
Molecular Weight	390.26 g/mol
Synonyms	2-Iodo-desipramine; 2-Iodo-10,11-dihydro-5H-dibenz[b,f]azepine; 5-[3-(Methylamino)propyl]-10,11-dihydro-2-iodo-5H-dibenz[b,f]azepine; 2-Iodo-5-(3-(methylamino)propyl)-10,11-dihydro-5H-dibenz[b,f]azepine; Desipramine 2-iodo derivative; Iododesipramine
EINECS	Contact for details

Quality Control

Our 2-Iododesmethylimipramine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.