Description

3-Bromo-5-Nitro-1H-Pyrazole is a versatile and highly functionalized heterocyclic building block, essential for advanced organic synthesis. Its unique structure, featuring both bromo and nitro substituents on the pyrazole core, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically active heterocycles.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its reactive sites for structural diversification.
• Material Science Research: Acts as a building block for creating specialized polymers, ligands for catalysis, and organic electronic materials due to its electron-withdrawing nitro group and potential for further functionalization.
• Chemical Biology & Proteomics: Employed in the design and synthesis of chemical probes and affinity tags for studying biological systems and protein interactions.
• Dye & Pigment Intermediate: Utilized in the development of advanced colorants and functional dyes where the nitro and bromo groups influence color and stability properties.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create more complex biaryl and conjugated systems.

Basic Information

Product Name	3-Bromo-5-Nitro-1H-Pyrazole
CAS No.	104599-38-4
Molecular Formula	C3H2BrN3O2
Molecular Weight	191.97 g/mol
Synonyms	1H-Pyrazole, 3-bromo-5-nitro-; 3-Bromo-5-nitropyrazole; 5-Nitro-3-bromo-1H-pyrazole; 3-Bromo-5-nitro-1H-pyrazole; 3-Br-5-NO2-Pyrazole
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Nitro-1H-Pyrazole is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.