Description

Ac-D-Bpa-Oh is a specialized, optically active amino acid derivative, specifically the N-acetylated form of D-4-boronophenylalanine. This compound is a critical building block in the development of targeted therapeutics and advanced diagnostic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of Boron Neutron Capture Therapy (BNCT) and other radiopharmaceuticals. Its defined stereochemistry and functional groups make it an essential precursor for synthesizing complex, biologically active molecules.

Application

• Boron Neutron Capture Therapy (BNCT): Serves as a key precursor for synthesizing boron-containing drugs designed for targeted cancer treatment.
• Radiopharmaceutical Development: Used in the research and synthesis of novel PET (Positron Emission Tomography) and SPECT (Single-Photon Emission Computed Tomography) imaging agents.
• Peptide & Protein Modification: Acts as a specialized amino acid analog for incorporating boron moieties into peptides and proteins for structural and functional studies.
• Medicinal Chemistry Research: Employed as a chiral building block in the design and synthesis of potential therapeutic agents targeting various diseases.
• Bioconjugation & Probe Synthesis: Utilized to create labeled probes for biochemical assays, biosensors, and targeted drug delivery systems.

Basic Information

Product Name	Ac-D-Bpa-Oh
CAS No.	104504-42-9
Molecular Formula	C11H14BNO5
Molecular Weight	251.05 g/mol
Synonyms	N-Acetyl-D-4-boronophenylalanine; N-Acetyl-D-BPA; Ac-D-BPA-OH; (R)-2-Acetamido-3-(4-boronophenyl)propanoic acid; D-4-(Boronophenyl)alanine, N-acetyl-; BOC Sciences Brand Name: BLD-BP-104504; D-Bpa(Ac)-OH; N-Acetyl-D-p-boronophenylalanine
EINECS	Contact for details

Quality Control

Our Ac-D-Bpa-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR/IR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our commitment to quality supports reproducible results in critical pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive nature, the container should be kept in secondary packaging or amber glass. For long-term storage, consider desiccant use to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.