Description

Disialosyl Le(A) CAS NO 104220-70-4 is a complex carbohydrate antigen, specifically a disialylated Lewis A blood group determinant. This compound is a critical reagent in glycobiology research for studying cell surface interactions, immune responses, and cancer biomarker discovery. It is primarily utilized by research institutions, diagnostic developers, and pharmaceutical companies engaged in the development of vaccines, therapeutic antibodies, and advanced diagnostic assays.

Application

• Glycobiology Research: Used as a standard or inhibitor in studies of carbohydrate-protein interactions, cell adhesion, and signaling pathways.
• Diagnostic Development: Serves as a key antigen for the production and calibration of immunoassays and biosensors targeting cancer-associated glycans.
• Vaccine Research: Employed in the design and evaluation of carbohydrate-based cancer vaccines and anti-adhesion therapies.
• Biomarker Discovery: Acts as a reference compound for profiling glycosylation changes in diseases, particularly in oncology.
• Enzyme Substrate: Utilized as a substrate for studying the activity of glycosyltransferases, glycosidases, and other modifying enzymes.
• Quality Control Standard: Provides a defined structure for quality control in the production of glycan arrays and other glyco-analytical tools.

Basic Information

Item	Detail
Product Name	Disialosyl Le(A)
CAS No.	104220-70-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Disialosyl Lewis A; Disialyl Lea; α-D-Neu5Ac-(2→3)-β-D-Gal-(1→3)-[α-L-Fuc-(1→4)]-β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-D-Glc; Sialyl Lewis A antigen (disialylated); CA19-9 related antigen; Blood group antigen Lea (disialylated); Disialyl Lacto-N-fucopentaose II
EINECS	Contact for details

Quality Control

Our Disialosyl Le(A) is produced under stringent conditions to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is characterized using advanced analytical techniques including NMR and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.