Description

7-Chloro-1-Cyclopropyl-1,4-Dihydro-8-Methyl-4-Oxo-3-Quinolinecarboxylic Acid is a high-purity pharmaceutical intermediate belonging to the quinolone carboxylic acid class. This compound is a critical building block in the synthesis of advanced antibiotic agents, offering significant value in the development of novel therapeutics. It is primarily required by pharmaceutical R&D laboratories, API manufacturers, and fine chemical suppliers serving the global antimicrobial sector.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A key intermediate in the production of next-generation quinolone and fluoroquinolone antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design, synthesis, and structure-activity relationship (SAR) studies of new antibacterial compounds.
• Process Chemistry & Scale-Up: Serves as a standard reference material and a starting material for process optimization and pilot-scale manufacturing.
• Fine Chemical Production: Supplied to fine chemical companies for further functionalization and integration into complex molecular architectures.
• Contract Manufacturing (CMO/CDMO): Essential raw material for contract manufacturing organizations specializing in antibiotic production.
• Analytical Standard: Used as a high-purity reference standard in quality control (QC) and analytical method development (e.g., HPLC, LC-MS).

Basic Information

Product Name	7-Chloro-1-Cyclopropyl-1,4-Dihydro-8-Methyl-4-Oxo-3-Quinolinecarboxylic Acid
CAS No.	103877-20-9
Molecular Formula	C14H12ClNO3
Molecular Weight	277.70 g/mol
Synonyms	7-Chloro-1-cyclopropyl-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-7-chloro-1,4-dihydro-8-methyl-4-oxo-3-quinolinecarboxylic Acid; 7-Chloro-1-cyclopropyl-8-methyl-4-oxoquinoline-3-carboxylic acid; Quinolonecarboxylic acid derivative (CP-99,219 intermediate); Intermediate for Quinolone Antibiotics; Balofloxacin Intermediate; 103877-20-9 (CAS Name)
EINECS	Contact for details

Quality Control

Our 7-Chloro-1-Cyclopropyl-1,4-Dihydro-8-Methyl-4-Oxo-3-Quinolinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.