Description

5-Amino-L-Cyclopropyl-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of modern fluoroquinolone antibiotics, valued for its precise stereochemistry and trifluoromethyl-substituted quinoline core. It is primarily required by pharmaceutical R&D departments, process chemists, and manufacturers engaged in the development and production of next-generation antibacterial agents.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: A crucial precursor in the synthesis of potent antibacterial agents like garenoxacin and other advanced-generation quinolones.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of novel antimicrobial compounds.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the final chemical steps to construct the complex molecular framework of finished drug substances.
• Process Chemistry & Scale-Up: Serves as a defined starting material for optimizing synthetic routes and scaling production from laboratory to commercial batch sizes.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs producing antibiotic APIs under cGMP guidelines for global pharmaceutical clients.

Basic Information

Product Name	5-Amino-L-Cyclopropyl-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid
CAS No.	103772-14-1
Molecular Formula	C13H10F3N3O3
Molecular Weight	313.23 g/mol
Synonyms	5-Amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; (S)-5-Amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; L-5-Amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; Garenoxacin intermediate; DW-224a intermediate; AM-1155 intermediate; 3-Quinolinecarboxylic acid, 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-, (S)-
EINECS	Contact for details

Quality Control

Our 5-Amino-L-Cyclopropyl-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid is manufactured under strict quality management systems. We provide material that meets exacting standards for pharmaceutical intermediate applications, with purity typically exceeding 98.0% (by HPLC). Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch. Our production can align with ICH guidelines, and we support audits and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Optical Rotation	Specific range provided per grade
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.