Description

1-Cyclopropyl-5-Amido-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3- Quinolinecarboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is a key synthetic precursor in the production of modern fluoroquinolone antibiotics, valued for its precise molecular structure which is critical for final API efficacy. It is essential for research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development and synthesis of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of potent fluoroquinolone antibiotic active pharmaceutical ingredients (APIs).
• Antibacterial Drug Research: Critical starting material in R&D for novel quinolone-based antibacterial compounds targeting resistant pathogens.
• Fine Chemical Synthesis: Used in multi-step organic synthesis processes requiring a high-purity, functionalized quinolone core.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of antibiotic drug substances.
• Academic & Industrial Research: Serves as a reference standard and reagent in medicinal chemistry studies exploring structure-activity relationships.

Basic Information

Product Name	1-Cyclopropyl-5-Amido-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3- Quinolinecarboxylic Acid Ethyl Ester
CAS No.	103772-13-0
Molecular Formula	C₁₆H₁₄F₃N₃O₄
Molecular Weight	369.30 g/mol
Synonyms	Ethyl 1-Cyclopropyl-5-Amino-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylate; 1-Cyclopropyl-6,7,8-Trifluoro-1,4-Dihydro-5-Amino-4-Oxo-3-Quinolinecarboxylic Acid Ethyl Ester; 5-Amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester; 103772-13-0; 5-Amino-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Ethyl Ester; Intermediate for Fluoroquinolone Antibiotics; Quinolone Carboxylic Acid Ester Derivative
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-5-Amido-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3- Quinolinecarboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.