Description

1-Cyclopropyl-5-Nitro-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3- Quinolinecarboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of modern fluoroquinolone antibiotics, valued for its precise molecular structure that imparts key pharmacological properties. It is primarily required by active pharmaceutical ingredient (API) manufacturers and fine chemical synthesis specialists within the global pharmaceutical and life sciences industries.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: A vital precursor in the multi-step synthesis of potent antibacterial agents such as ciprofloxacin, levofloxacin, and other third-generation quinolones.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and development of new antibacterial compounds with improved efficacy and spectrum of activity.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes for the cost-effective and scalable production of antibiotic APIs under GMP conditions.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory compliance testing in pharmaceutical manufacturing.
• Custom Synthesis Building Block: Utilized by fine chemical suppliers for the preparation of specialized derivatives and analogs for biological testing.

Basic Information

Product Name	1-Cyclopropyl-5-Nitro-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3- Quinolinecarboxylic Acid Ethyl Ester
CAS No.	103772-12-9
Molecular Formula	C15H12F3N3O5
Molecular Weight	371.27 g/mol
Synonyms	Ethyl 1-Cyclopropyl-5-Nitro-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylate; 1-Cyclopropyl-6,7,8-Trifluoro-1,4-Dihydro-5-Nitro-4-Oxo-3-Quinolinecarboxylic Acid Ethyl Ester; 103772-12-9; Ciprofloxacin Intermediate; Ethyl 1-Cyclopropyl-6,7,8-Trifluoro-1,4-Dihydro-5-Nitro-4-Oxo-3-Quinolinecarboxylate; 3-Quinolinecarboxylic Acid, 1-Cyclopropyl-1,4-Dihydro-5-Nitro-6,7,8-Trifluoro-4-Oxo-, Ethyl Ester
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-5-Nitro-6,7,8-Trifluoro-1,4-Dihydro-4-Oxo-3- Quinolinecarboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance with cGMP and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.