Description

3-Quinolinecarboxylic Acid, 8-Chloro-1-Cyclopropyl-7-(3,5-Dimethyl-1-Piperazinyl)-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, complex heterocyclic compound that serves as a critical advanced pharmaceutical intermediate. Its value lies in its role as a key building block for the synthesis of novel fluoroquinolone antibiotics, enabling the development of next-generation antimicrobial agents. This product is essential for research institutions and pharmaceutical manufacturers engaged in the development and production of active pharmaceutical ingredients (APIs) targeting resistant bacterial infections.

Application

• Pharmaceutical Intermediate: Primary use as a core synthon in the synthesis of advanced fluoroquinolone antibiotic APIs.
• Antimicrobial Research: Serves as a key scaffold in medicinal chemistry for developing new antibacterial compounds with improved efficacy and spectrum.
• Process Chemistry: Used in scale-up and optimization studies for the commercial manufacturing of antibiotic drugs.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for the production of client-specific drug substances.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 8-Chloro-1-Cyclopropyl-7-(3,5-Dimethyl-1-Piperazinyl)-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	103481-72-7
Molecular Formula	C19H21ClFN3O3
Molecular Weight	393.84 g/mol
Synonyms	8-Chloro-1-cyclopropyl-7-(3,5-dimethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Clinafloxacin Intermediate; PD 127391 Intermediate; AM-1091 Intermediate; (1-Cyclopropyl-6-fluoro-1,4-dihydro-8-chloro-7-(3,5-dimethyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid); 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-chloro-7-(3,5-dimethylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical synthesis. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.