Description

6'-Hydroxy Doxazosin is a key pharmaceutical intermediate and metabolite of the antihypertensive agent doxazosin. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, analytical reference standard suppliers, and manufacturers engaged in the production of high-purity active pharmaceutical ingredients (APIs) and their related substances.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and development of doxazosin-based APIs and related analogs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to understand the metabolic pathway and pharmacokinetic profile of doxazosin.
• Pharmacology Research: Employed in preclinical and clinical research to investigate the activity, efficacy, and safety profile of metabolic products.
• Quality Control & Impurity Profiling: Serves as a known impurity or reference compound in the HPLC/LC-MS analysis of doxazosin drug substances and finished products to ensure purity and compliance.
• Academic Research: Utilized in university and institutional labs for studies in medicinal chemistry, drug design, and metabolic engineering.

Basic Information

Product Name	6'-Hydroxy Doxazosin
CAS No.	102932-29-6
Molecular Formula	C23H25N5O5
Molecular Weight	451.48 g/mol
Synonyms	6'-Hydroxydoxazosin; Doxazosin 6'-Hydroxy Metabolite; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine-6-ol; UK-338,003; UK 338003; UK338003; 6'-OH-Doxazosin
EINECS	Contact for details

Quality Control

Our 6'-Hydroxy Doxazosin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets high-purity standards suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.