Description

2-Cyclopropyl-3,4-Dihydro-1H-Isoquinoline Chloride is a versatile and high-value organic salt, primarily utilized as a key synthetic intermediate in advanced pharmaceutical research and development. Its unique fused bicyclic structure containing a cyclopropyl group makes it a critical building block for constructing complex molecules with potential biological activity. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, and other therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the isoquinoline scaffold can contribute to novel modes of action.
• Ligand and Catalyst Synthesis: Acts as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.
• Academic & R&D: A valuable reagent for university and institutional research in organic chemistry, medicinal chemistry, and chemical biology.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	2-Cyclopropyl-3,4-Dihydro-1H-Isoquinoline Chloride
CAS No.	102395-77-7
Molecular Formula	C12H14ClN
Molecular Weight	207.70 g/mol
Synonyms	2-Cyclopropyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; 1,2,3,4-Tetrahydro-2-cyclopropylisoquinoline hydrochloride; 2-Cyclopropyl-3,4-dihydro-1H-isoquinolinium chloride; Cyclopropyltetrahydroisoquinoline HCl; 2-Cyclopropyl-1,2,3,4-tetrahydroisoquinoline HCl; 102395-77-7; 2-Cyclopropyl-1,2,3,4-tetrahydroisoquinoline hydrochloride salt
EINECS	Contact for details

Quality Control

Our 2-Cyclopropyl-3,4-Dihydro-1H-Isoquinoline Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.