Description

1-Chloro-2-Ethoxy-4-Nitrobenzene is a versatile nitroaromatic compound that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for creating complex molecules with specific electronic and steric properties. This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring a nitro-substituted aromatic core.
• Agrochemical Synthesis: Used in the development of herbicides, pesticides, and fungicides, where the nitro and chloro groups are essential for biological activity.
• Dye and Pigment Manufacturing: Serves as an intermediate in the production of azo dyes and other complex colorants.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D labs exploring novel organic reactions and heterocyclic chemistry.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig amination for constructing biaryl structures.

Basic Information

Product Name	1-Chloro-2-Ethoxy-4-Nitrobenzene
CAS No.	102236-22-6
Molecular Formula	C8H8ClNO3
Molecular Weight	201.61 g/mol
Synonyms	2-Chloro-1-Ethoxy-4-Nitrobenzene; 4-Nitro-2-Chlorophenetole; 1-Chloro-2-ethoxy-4-nitro-benzene; 2-Chloro-4-nitrophenetole; Benzene, 1-chloro-2-ethoxy-4-nitro-; 4-Nitro-2-chloro-1-ethoxybenzene; 2-Ethoxy-5-nitrochlorobenzene
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-Ethoxy-4-Nitrobenzene is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming identity, assay, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP for pharmaceutical intermediates and ISO standards for industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents. The container should be kept tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	65 - 68 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.