Description

8-Chloroquinazolin-4(1H)-One is a high-purity, versatile quinazolinone derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its role as a key synthetic intermediate in the development of novel pharmaceutical agents and bioactive molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of potential kinase inhibitors, anticancer agents, and other biologically active quinazoline-based compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators, leveraging its heterocyclic core structure.
• Fine Chemical Synthesis: Serves as a versatile scaffold for constructing complex molecules in custom synthesis and process development for specialty chemicals.
• Academic & R&D: Employed in medicinal chemistry research for structure-activity relationship (SAR) studies and the discovery of new therapeutic candidates.
• Material Science: Investigated as a monomer or precursor for the synthesis of specialty polymers and organic electronic materials.

Basic Information

Product Name	8-Chloroquinazolin-4(1H)-One
CAS No.	101494-95-5
Molecular Formula	C8H5ClN2O
Molecular Weight	180.59 g/mol
Synonyms	8-Chloro-1,4-dihydroquinazolin-4-one; 8-Chloro-4-hydroxyquinazoline; 8-Chloro-4(1H)-quinazolinone; 8-Chloroquinazolin-4-ol; 4-Hydroxy-8-chloroquinazoline; 8-Chloro-4-quinazolinol; 8-Chloro-4(3H)-quinazolinone (tautomer); 101494-95-5
EINECS	Contact for details

Quality Control

Our 8-Chloroquinazolin-4(1H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR), to ensure it meets exacting standards for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. The product is light-sensitive and should be stored away from light as indicated.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.