Description

6-Astatomethyl-19-Norcholest-5(10)-En-3-Ol is a highly specialized, astatine-containing sterol derivative, representing a critical building block in advanced radiopharmaceutical research. Its core value lies in its unique molecular architecture, which is engineered for targeted radiolabeling applications, enabling precise diagnostic and therapeutic modalities. This compound is essential for research scientists and developers in the fields of nuclear medicine, oncology research, and molecular imaging, particularly for investigating novel α-emitting radiopharmaceuticals.

Application

• Precursor for Targeted Alpha Therapy (TAT) Agents: Serves as a key intermediate in the synthesis of astatine-211 labeled compounds for cancer treatment.
• Research Tool in Nuclear Medicine: Used in preclinical studies to develop new radiopharmaceuticals for diagnostic imaging and radiotherapy.
• Molecular Probe Development: Acts as a scaffold for creating probes that study receptor expression and biodistribution in disease models.
• Oncology Research: Utilized in academic and pharmaceutical R&D to explore novel mechanisms for targeted radiation delivery to tumors.
• Radiochemistry Synthesis: A critical starting material for chemists specializing in the labeling of biomolecules with astatine radioisotopes.

Basic Information

Product Name	6-Astatomethyl-19-Norcholest-5(10)-En-3-Ol
CAS No.	101387-37-5
Molecular Formula	C27H45AtO
Molecular Weight	~528.6 g/mol (excluding isotope mass variation)
Synonyms	19-Nor-6-astatomethylcholest-5(10)-en-3-ol; 6-(Astatomethyl)-19-norcholest-5(10)-en-3β-ol; Astatine-labeled cholesterol analog; At-211 precursor sterol; Radiolabeled sterol intermediate; 6-AtCH2-19-Nor-Cholestene-ol
EINECS	Contact for details

Quality Control

Every batch of 6-Astatomethyl-19-Norcholest-5(10)-En-3-Ol is synthesized and handled under stringent, controlled conditions to ensure research-grade integrity and consistency. Our quality assurance protocol includes rigorous analytical characterization to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing specific batch data, including radiochemical purity (where applicable) and analytical methods (HPLC, NMR), is provided to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity, this material must be stored under an inert atmosphere (e.g., argon or nitrogen) at recommended cold temperatures (e.g., -20°C or lower) to minimize decomposition and oxidation. Handle and store only in facilities appropriate for radioactive materials.

Specification

Item	Specification
Appearance	White to Off-White Solid
Identification (HPLC)	Conforms to Reference Standard
Identification (NMR)	Conforms to Structure
Purity (HPLC)	≥ 95% (Chemical Purity)
Specific Activity (If Radioactive)	Available upon request
Radiochemical Purity (If Radioactive)	≥ 95%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.