Description

Microcystin-Lr CAS NO 101043-37-2 is a potent cyclic heptapeptide hepatotoxin produced by certain freshwater cyanobacteria. This compound is of critical importance as a reference standard and research tool for environmental monitoring, toxicology studies, and water safety analysis. It is primarily needed by analytical laboratories, environmental testing agencies, and research institutions focused on public health and aquatic ecosystem management.

Application

• Analytical Reference Standard: Primary use for the calibration and validation of analytical methods (e.g., HPLC, LC-MS/MS) for cyanotoxin detection in water samples.
• Environmental Monitoring & Risk Assessment: Critical for quantifying toxin levels in drinking water sources, recreational waters, and algal blooms to assess public health risks.
• Toxicological Research: Used in laboratory studies to investigate the mechanisms of hepatotoxicity, including protein phosphatase inhibition and oxidative stress.
• Method Development & Proficiency Testing: Essential for developing new detection protocols and for use in inter-laboratory comparison programs to ensure analytical accuracy.
• Biochemical Research: Serves as a specific inhibitor of protein phosphatases PP1 and PP2A in cell signaling and metabolic pathway studies.
• Quality Control & Assurance: Employed by manufacturers of test kits and immunoassays for cyanotoxins to verify kit performance and specificity.

Basic Information

Item	Details
Product Name	Microcystin-Lr
CAS No.	101043-37-2
Molecular Formula	C49H74N10O12
Molecular Weight	995.17 g/mol
Synonyms	Microcystin-LR; MC-LR; Cyanoginosin-LR; [Dha7]Microcystin-LR; Cyclo(-D-Ala-L-Leu-erythro-β-methyl-D-isoAsp-L-Arg-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid-D-Glu-N-methyldehydroAla); Lethal Toxin from *Microcystis aeruginosa*; (3S,4S,8S,9S,10E,12E,14S,16S,18S,19S,22R,35S)-19-(2-Amino-2-oxoethyl)-22-[(1S,2S,5S,6R)-2-carboxy-4-[(E)-3-methoxy-2-methylprop-1-en-1-yl]-3,3-dimethyl-1,5-dioxo-6-(2-phenylethyl)piperazin-1-ium-4-yl]-14-ethyl-4,6,9,16,18-pentamethyl-3-[(2S)-1-methyl-2-[(methylamino)carbonyl]propyl]-2,11,15,20,23,25-hexaoxo-1-oxa-10,24-diazaheptacyclo[11.11.0.03,10.04,9.014,18.016,35.020,23]pentatriacont-12-ene-35-carboxylate
EINECS	Contact for details

Quality Control

Our Microcystin-Lr is produced and handled under strict quality-controlled conditions suitable for research and analytical applications. Each batch is characterized using advanced spectroscopic and chromatographic techniques to ensure identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, identification, and impurity profiles is provided with every shipment to support your compliance and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Due to its hygroscopic (moisture-sensitive) nature, containers should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95% (Area % at 238 nm)
Water Content (KF)	≤ 5.0 %
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.