Description

2-(T-Butyldimethylsilyloxy)-6-Bromonaphthalene is a high-value, protected naphthalene derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in providing a versatile, reactive bromine site while the tert-butyldimethylsilyl (TBDMS) protecting group offers excellent stability under a wide range of reaction conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for constructing complex polycyclic aromatic frameworks and functionalized naphthalene cores.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators that require functionalized naphthalene structures.
• Liquid Crystal & OLED Materials: Serves as a precursor for creating organic semiconductors, charge-transport materials, and emissive layers in display technologies.
• Polymer Chemistry: Monomer for synthesizing specialty polymers with enhanced thermal stability and optoelectronic properties.
• Cross-Coupling Reactions: Ideal substrate for Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl and complex aromatic systems.
• Organic Synthesis Research: A versatile reagent in academic and industrial R&D for exploring new catalytic methodologies and constructing complex molecular architectures.

Basic Information

Product Name	2-(T-Butyldimethylsilyloxy)-6-Bromonaphthalene
CAS No.	100751-65-3
Molecular Formula	C₁₆H₂₁BrOSi
Molecular Weight	337.33 g/mol
Synonyms	6-Bromo-2-[(tert-butyldimethylsilyl)oxy]naphthalene; 2-Bromo-6-[(tert-butyldimethylsilyl)oxy]naphthalene; 2-(tert-Butyldimethylsiloxy)-6-bromonaphthalene; TBDMS Protected 6-Bromo-2-naphthol; 6-Bromo-2-naphthol TBDMS ether; 2-Bromo-6-(tert-butyldimethylsilyloxy)naphthalene; 2-(Tert-butyldimethylsilyloxy)-6-bromonaphthalene; Naphthalene, 6-bromo-2-[(1,1-dimethylethyl)dimethylsilyl]oxy]-
EINECS	Contact for details

Quality Control

Our 2-(T-Butyldimethylsilyloxy)-6-Bromonaphthalene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our standard quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable performance in your critical reaction sequences.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to fluoride ions and strong alkali; keep away from such materials. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maximize shelf-life stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.