Description

6'-Aminospiro[Cyclopentane-1,3'-Indolin]-2'-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic indoline structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, complex molecules with potential therapeutic applications. It is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors for drug discovery programs targeting central nervous system (CNS) disorders, oncology, and other disease areas.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing spirocyclic compounds in drug discovery libraries for high-throughput screening.
• CNS Drug Development: Used in the synthesis of potential therapeutics for neurological and psychiatric conditions, leveraging the indoline core's bioactivity.
• Oncological Agent Synthesis: Employed as a precursor in the development of novel small-molecule inhibitors and targeted cancer therapies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.
• Academic Research: Utilized in university and institutional labs for studying spirocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	6'-Aminospiro[Cyclopentane-1,3'-Indolin]-2'-One
CAS No.	100510-66-5
Molecular Formula	C13H16N2O
Molecular Weight	216.28 g/mol
Synonyms	6'-Amino-1'H-spiro[cyclopentane-1,3'-indol]-2'(2'H)-one; 6'-Amino-2,3-dihydrospiro[indole-3,1'-cyclopentane]-2-one; 6'-Aminospiro(cyclopentane-1,3'-indolin)-2'-one; 2'-Oxo-6'-aminospiro(cyclopentane-1,3'-indoline); Spiro[cyclopentane-1,3'-indolin]-2'-one, 6'-amino-; 6-Aminospiro[cyclopentane-1,3'-indolin]-2'-one
EINECS	Contact for details

Quality Control

Our 6'-Aminospiro[Cyclopentane-1,3'-Indolin]-2'-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) documenting full specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.